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In the United States, phencyclidine (PCP), also referred to as angel dust, is classified as a Schedule I substance due to its psychoactive properties (4-MEO-PCP). A new commercial production of 4-methoxy PCP, a designer drug, is an analog of PCP. It forms a stronger binding with the σ-2 receptor (Ki = 143 nM) than it does with the NMDA receptor (Kis = 404 nM) and serotonin transporter (844 nM), respectively.

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The dissociative anesthetic 4-methoxyphencyclidine, sometimes referred to as 4-MeO-PCP or methoxydine, has been sold online. In 1965, Parke-Davis medicinal chemist Victor Maddox published the first report on the synthesis of 4-MeO-PCP.The source: According to a 1999 assessment by a chemist writing under the pen name John Q. Beagle, the potency of 4-MeO-PCP in humans was allegedly lower than that of PCP. Beagle claimed that 4-MeO-PCP was 70% more effective than PCP when he provided an extensive report of its synthesis and qualitative effects two years later.

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A business operating under the name CBAY offered 4-MeO-PCP, the first arylcyclohexylamine research chemical to be marketed online, in late 2008. It was followed by numerous related compounds, including 3MeO-PCP and methoxetamine.4-MeO-PCP is orally active in a dosage range similar to ketamine, with some users needing dosages exceeding 100 mg for desired effects. It has a stronger affinity for the NMDA receptor than ketamine but a lower affinity than PCP for the receptor. Users have reported significant variations in active dosage; samples sold on the black market may contain unreacted PCC and other contaminants, which helps to explain some of these disparities.